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Urogenital Chlamydia trachomatis infection remains prevalent and causes substantial reproductive morbidity. Recent studies have raised concern about the efficacy of azithromycin for the treatment of chlamydia infection. We conducted a randomized trial comparing oral azithromycin with doxycycline for the treatment of urogenital chlamydia infection among adolescents in youth correctional facilities, to evaluate the noninferiority of azithromycin 1 g in one dose to doxycycline mg twice daily for 7 days. The treatment was directly observed. The primary end point was treatment failure at 28 days after treatment initiation, with treatment failure determined on https://www.sunrayvet.com the basis of nucleic acid amplification testing, sexual history, and outer membrane protein A OmpA genotyping of C. Among the participants enrolled, were randomly assigned to receive azithromycin, and were randomly assigned to receive doxycycline. There were no treatment failures in the doxycycline group. In the azithromycin group, treatment failure occurred in 5 participants 3.
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A total of participants in four youth correctional facilities were enrolled and underwent randomization? Macrolide antibiotics have a broad spectrum of activity and are commonly used to treat mild to moderate bacterial infections including chlamydia.
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Important research findings dictate a return to doxycycline as the treatment of choice for uncomplicated urethral, cervical, and oral chlamydia infections, for NGU and MPC, and as co-treatment for uncomplicated gonorrhea. In a use-effectiveness study at seven public health clinics, doxycycline and azithromycin were equivalent for treating genital chlamydia infection and preventing recurrences.
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