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Food and Drug Administration FDA is warning health care professionals to avoid prescribing the antifungal medicine ketoconazole oral tablets to treat skin and nail fungal infections. Use of this medication carries the risk of serious liver damage, adrenal gland problems, and harmful interactions with other medicines that outweigh its benefit in treating these conditions, which are not approved uses of the drug. We approved label changes for oral ketoconazole tablets in to reflect these serious risks and to remove the indication for treatment of skin and nail fungal infections. In the 18 months ending in June, skin and nail fungal infections were the only diagnoses 1 cited for the use of oral ketoconazole in an office-based physician surveys database. Health care professionals should use ketoconazole tablets only to treat serious fungal infections when no other antifungal therapies are available.
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The antifungal agent which has certain against dermatophytes, yeasts, dimorphic fungi and eumycetes. It is also safe against staphylococci and streptococci.
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