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The highest weekly average for the coiTesponding period of either of the five preceding years was in Thus far, therefore, the mortality of the present year has been mucb in excess over that of recent years.
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Irene (taken for 1 to 6 years) 12.02.2019
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The serotonin 5-HT 3 receptors are located on the nerve terminals of the vagus in the periphery, and centrally in the chemoreceptor trigger zone of the area postrema Label, 3, 4. Moreover, the effect of ondansetron on the QTc interval was evaluated in a double-blind, randomized, placebo and positive moxifloxacin controlled, crossover study in 58 healthy adult men and women 9, Ondansetron was tested at single doses of 8 mg and 32 mg infused intravenously over 15 minutes 9, The magnitude of QTc prolongation with ondansetron is expected to be greater if the infusion rate is faster than 15 minutes 9, The 32 mg intravenous dose of ondansetron must not be administered 9, On the basis of pharmacokinetic-pharmacodynamic modelling, an 8 mg oral dose of ondansetron is predicted to cause a mean QTcF increase of 0.
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Cyclosporine: Administration of nonsteroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine induced toxicity, possibly due to decreased synthesis of renal prostacyclin. NSAIDs should be used with caution in patients taking cyclosporine, and renal function should be monitored carefully.
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