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Common side effects include headache, low blood pressure, nausea, and constipation. Verapamil was approved for medical use in the United States in Verapamil is used for controlling ventricular rate in supraventricular tachycardia and migraine headache prevention. Verapamil is also used intra-arterially to treat cerebral vasospasm. The most common side effect of verapamil is constipation 7. Other side effects include dizziness 3. Acute overdose is often manifested by nausea, weakness, slow heart rate, dizziness, low blood pressure, and abnormal heart rhythms. Plasma, serum, or blood concentrations of verapamil and norverapamil, its major active metabolite, may be measured to confirm a diagnosis of poisoning in hospitalized patients or to aid in the medicolegal investigation of fatalities. Verapamil's mechanism in all cases is to block voltage-dependent calcium channels. Since calcium channels are especially concentrated in the sinoatrial and atrioventricular nodes, these agents can be used to decrease impulse conduction through the AV node, thus protecting the ventricles from atrial tachyarrhythmias.

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  • Verapamil is considered alone or together with other medications to treat heart rhythm problems, severe chest pain angina, or periodic blood pressure hypertension.
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Before taking verapamil, tell your doctor if you are allergic to any drugs, or if you have kidney disease, liver disease, congestive heart failure, or a nerve-muscle disorder such as myasthenia gravis or muscular dystrophy. Verapamil may be only part of a complete program of treatment that also includes diet, exercise, and other medications. It works by relaxing the muscles of your heart and blood vessels.

   
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