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Phenothiazines, including chlorpromazine Thorazine and thioridazine Mellaril, are concentrated in uveal tissue and RPE by binding to melanin granules. High-dose chlorpromazine therapy commonly results in abnormal pigmentation of the eyelids, interpalpebral conjunctiva, cornea, and anterior lens capsule; anterior and posterior subcapsular cataracts may develop. However, pigmentary retinopathy from chlorpromazine is rare, if it occurs at all. In contrast, thioridazine causes severe retinopathy that can develop within a few weeks or months of high-dose utilization. Fundus changes in the late stages may be confused with choroideremia or Bietti crystalline corneoretinal dystrophy; the symptoms include visual field loss and night blindness.

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Dasatinib: Major Do not administer H2-blockers with dasatinib due to the potential for decreased dasatinib exposure and reduced efficacy. Consider using an antacid if acid suppression therapy is needed. Administer the antacid at least 2 hours prior to or 2 hours after the dose of dasatinib.

   
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