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Furthermore, using multiple agents to lower doses may reduce side effects, and thus improve patient compliance. The issue arises as to which fixed combinations provide the most benefits. In addition, the reported incidence of peripheral oedema was lower in the combination group.
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Initially, 5 mg or less PO may be appropriate to reduce the risk of excessive INR elevation and potential bleeding events. Initially, 2 to 3 mg PO may be appropriate to reduce the risk of excessive INR elevation and potential bleeding events. These patients have a higher sensitivity to warfarin probably due to effects of cardiopulmonary bypass and concomitant therapies.
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