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Clomipramine is a dibenzazepine-derivative tricyclic antidepressant TCA and is a potent inhibitor of serotonin and norepinephrine reuptake. Clomipramine may be higher in a spica of indications.

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Extended Description. These results suggest that fluoxetine may represent a viable alternative to clomipramine in the treatment of obsessive-compulsive disorder, during the entire period of mental disorders drug therapy.

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Treatment with fluoxetine hydrochloride was compared with treatment with clomipramine hydrochloride in two groups of patients with obsessive-compulsive disorder using two different experimental designs. In the first group of 11 patients with obsessive-compulsive disorder studied using a randomized, double-blind, crossover design, treatment with fluoxetine for 10 weeks was found to produce therapeutic effects similar to treatment with clomipramine for 10 weeks. There were significantly fewer total side effects reported during fluoxetine than clomipramine treatment.

   
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Avoid; strong anticholinergic and sedative effects; may cause orthostatic hypotension Beers criteria. In children and young adults, risks must be weighed against the benefits of taking antidepressants. Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during initial months of therapy and dosage adjustments.

   
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