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Common side effects include headaches, heartburn, and flushed skin. Sildenafil acts by blocking phosphodiesterase 5 PDE 5, an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. The primary indication of sildenafil is treatment of erectile dysfunction inability to sustain a satisfactory erection to complete intercourse. Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. Tentative evidence suggests that sildenafil may help men who experience antidepressant -induced erectile dysfunction. Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon ; these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes. Sildenafil has been studied for high-altitude pulmonary edema, but its use is currently not recommended for that indication. In clinical trials, the most common adverse effects of sildenafil use included headache, flushing, indigestion, nasal congestion, and impaired vision, including photophobia and blurred vision. In July, the FDA found that sildenafil could lead to vision impairment in rare cases, and a number of studies have linked sildenafil use with non-arteritic anterior ischemic optic neuropathy.
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Substance lowers the blood pressure in a body of human males and women too. But it has the interesting side effect of it only relevant for men : it directs some of the blood into penile cavities causing a sturdy erection only occurring after physical stimulation. But, as during time a span of years of recurrent use, it creates a certain resistance of the body to the main active substance, some patients may feel a need to intake mg pill. But not over this amount per every twenty-four hours if otherwise is prescribed by a doctor. Use it shortly before the anticipated sexual intercourse to receive strong erection lasting for approximately 1…4 hours. When erection goes away, do not take another pill within 24 hours from the intake of the first one in order not to provoke health deterioration.
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We respect your privacy. It's the active ingredient in both branded Viagra and the drug Revatio, which is a lower dose than Viagra and approved to treat pulmonary arterial hypertension. At a lower dose, sildenafil is approved to treat pulmonary arterial hypertension—the higher dose is reserved for treating erectile dysfunction ED.
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