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Anthracyclines are the most effective drugs in the treatment of breast cancer, and the addition of a taxane to an anthracycline-containing regimen, after or concurrently with anthracycline treatment, appears to provide significant benefit, particularly in node-positive cases and the combination of paclitaxel with anthracycline has been reported as an active regimen in improvement of disease-free survival and overall survival. A large number of adjuvant taxane studies have been reported. One method for increasing dose intensity in high risk patients in order to achieve the most benefit of maximum dose intensity is reducing the conventional drug dose intervals dose-dense regimen. Clinical trials suggested that paclitaxel was more effective and less myeoltoxic taxane than docetaxel and the low-dose weekly paclitaxel might be superior to higher doses given less frequently in both metastatic and adjuvant setting. The dose-dense regimens significantly prolonged both disease-free survival and overall survival without increasing toxicity. Since the optimal schedule of administration of epirubicin and cyclophosphamide plus paclitaxel and sequence-dependent toxicity have not been elucidated yet, further clinical trials with higher sample size are suggested.

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