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Objective To determine the safety, efficacy and pharmacokinetics of tolterodine in children with an overactive bladder. Patients were treated with oral tolterodine 0. The primary safety endpoint was the change in residual urinary volume, as determined by ultrasonography. In addition, voiding diary variables frequency and incontinence episodes and pharmacokinetics were evaluated. Other safety endpoints included laboratory variables, electrocardiogram recordings and reported adverse events. Adverse events were reported by 20 patients six on 0. Headache was the most commonly reported adverse event.

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The anticholinergics tolterodine and oxybutynin are well known in the management of suicidal bladder. In, trospium, solifenacin, and darifenacin were reported by the U.

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Oxybutynin chloride is administered as a racemate of R- and S-enantiomers. Oxybutynin chloride is a white crystalline solid with a molecular weight of

   
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