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Lexapro escitalopram and Zoloft sertraline are SSRIs selective serotonin reuptake inhibitors indicated for the treatment of depression and other psychological conditions. An SSRI works by increasing serotonin levels in the brain, which helps improve symptoms. Although Lexapro and Zoloft are similar, they have notable differences in their indications as well as cost. Lexapro is an SSRI indicated for acute and maintenance treatment of major depressive disorder MDD in adolescents aged years and adults, and acute treatment of generalized anxiety disorder GAD in adults. Both drugs have a long list of serious warnings, which are included in the warning section below. Additionally, you may experience other, more common adverse effects from Lexapro or Zoloft.

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