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Side effects of norethisterone include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increased hair growth. Norethisterone was discovered in and was one of the first progestins to be developed. Norethisterone is used as a hormonal contraceptive in combination with an estrogen — usually ethinylestradiol EE — in combined oral contraceptive pills and alone in progestogen-only pills. Another way in which norethisterone may be acting to reduce endometrial pain is via inhibition of ovulation. At contraceptive and hormone replacement dosages 0. In most clinical studies of norethisterone for contraception or menopausal hormone therapy, the drug has been combined with an estrogen, and for this reason, it is difficult to determine which of the side effects were caused by norethisterone and which of them were caused by estrogen in such research. In clinical studies, the most common side effect with NETE has been menstrual disturbances, including prolonged bleeding or spotting and amenorrhea.
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