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Application of HLA genotyping as a screening tool has important limitations and must never substitute for appropriate clinical vigilance and patient management. Patients with a history of adverse hematologic reaction to any drug may be particularly at risk of bone marrow depression. Some of these events have been fatal or life-threatening.
Helmut (taken for 2 to 6 years) 13.05.2016
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The elimination half-life of oral TENORMIN is approximately 6 to 7 hours, and there is no alteration of the kinetic profile of the drug by chronic administration. Declines from peak levels are rapid 5- to fold during the first 7 hours; thereafter, plasma levels decay with a half-life similar to that of orally administered drug.
Siegmund (taken for 2 to 4 years) 04.02.2018
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