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The Lopressor Intervention Trial LIT was a double-blind, randomized, placebo-controlled, multicentre study designed to evaluate the effect of oral metoprolol on overall mortality in patients surviving a recent acute myocardial infarction. Patient enrollment began in August and ended on 15 April, with patients on placebo and on metoprolol. Hospitalized patients, 45 to 74 years of age, began therapy from 6 to 16 days after their myocardial infarction. Two primary analyses were planned: total mortality among all randomized patients at 7 and at 12 months of trial entry. After 7 months of treatment there were 54 deaths in the placebo group and 42 deaths in the metoprolol group. After 1 year there were 62 deaths in the placebo group and 65 in the metoprolol group.

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