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Mirtazapine is the first of a new class of antidepressants, the noradrenergic and specific serotonergic antidepressants NaSSA. However, since the drug is extensively metabolised by the hepatic cytochrome P CYP system and is excreted mainly in the urine, its clearance may be reduced by hepatic or renal impairment. In vivo data from a study in extensive and poor metabolisers of debrisoquine indicate that strong inhibitors of CYP2D6 would have no effect on the concentration of racemic mirtazapine. This therapeutic advantage was subsequently maintained during treatment, with mirtazapine proving significantly superior to placebo at treatment end-point in the majority of studies. In comparative trials, the antidepressant efficacy of mirtazapine was comparable with that of tricyclic antidepressants such as amitriptyline, clomipramine and doxepin, and in 2 studies superior to that of trazodone and fluoxetine. Mirtazapine appears to have a broad spectrum of activity, reflected in its efficacy in a variety of clinical settings.

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Antidepressants increased the risk compared to placebo of suicidal thinking and behavior suicidality in children, adolescents, and young adults in short-term studies of major depressive disorder MDD and other psychiatric disorders. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide.

  • Epub Feb 8.
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Common side effects include increased weight, sleepiness, and dizziness. Mirtazapine came into medical use in the United States in Mirtazapine is primarily used for major depressive disorder and other mood disorders.

   
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Ute (taken for 3 to 7 years) 11.12.2017

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Mirtazapine is a moderate antagonist at muscarinic receptors, resulting in a relatively low incidence of anticholinergic side effects associated with its use. From: Heart and Toxins, Abdulrahman Al-Majed

   
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Boris (taken for 3 to 7 years) 20.10.2016

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Dosing interval in hepatic impairment : Use with caution and monitor plasma levels and patient response. Patients with renal failure should receive a reduced dosage initially and be closely monitored.

   
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Attila (taken for 3 to 7 years) 30.05.2019

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Yellow nail syndrome: analysis of 41 consecutive patients. What to do if you miss a dose: If you forget to take your dose, remeron tabl 50x25mg take it as soon as you remember. Benzodiazepines are used because they are less reinforcing than ethanol among alcoholics.

   
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Renate (taken for 3 to 4 years) 28.01.2017

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Write to the Court about why you do or do not like the Barr Settlement. My acne started flaring again so I just went to see a dermatologist today and was prescribed Minocyclin for 6 weeks and Clyndoxyl gel.

   
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Agathe (taken for 1 to 6 years) 29.04.2019

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