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The medication Thorazine belongs to a class of drugs known as antipsychotics and antiemetics. It is used for the management of symptoms of psychotic disorders and manic-depressive type illness, treatment of schizophrenia, for providing relief from restlessness and anxiety before surgery, controlling nausea and vomiting. It is also used for acute intermittent porphyria a blood pigment disorder, as an adjunct therapy in the treatment of tetanus. It is used to provide relief from persistent hiccups. This medication is also used to treat severe behavioural problems in children of 1 to 12 years of age with hyperexcitability, impulsivity, difficulty maintaining focus and attention, aggressivity, and poor frustration tolerance. Take Thorazine exactly as prescribed by your doctor.

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A French surgeon, Henri Laborit, discovered the first antipsychotic drug, chlorpromazine Thorazine, in while experimenting with compounds to enhance anesthesia. Clozapine, another product of serendipitous discovery, is unique in providing substantially greater efficacy in the treatment of psychosis than most other antipsychotics; however, the mechanism responsible for the efficacy of clozapine remains unclear, and metabolic side effects and the risk of agranulocytosis have limited its use. In this issue of the Journal, Koblan et al. Administration of SEP was associated with some somnolence and gastrointestinal side effects; neurologic and metabolic side effects were similar to those with placebo Sudden cardiac death occurred in 1 of patients in the SEP group. The SEP molecule emerged from a proprietary screening process as a new compound without significant affinity for D2 or 5-HT 2A receptors that mimicked the behavioral effects of https://www.md.com D2-receptor—antagonist drugs in mice and was found to bind with high affinity to the trace amine—associated receptor 1 TAAR1 and to serotonin 5-HT type 1A and type 1D receptors. If the results of this trial are replicated in larger trials of longer duration, this class of drugs may provide a valuable new therapeutic option for psychosis and the negative symptoms of schizophrenia, possibly without the adverse effects associated with direct D2-receptor antagonism.

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