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The clinical relevance of this displacement is unknown. In an in vitro study, valproate increased the unbound fraction of warfarin by up to The therapeutic relevance of this is unknown; however, coagulation tests should be monitored if valproate therapy is instituted in patients taking anticoagulants.

   
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In a 6-month extension of a randomized, placebo-controlled study utilizing galantamine conventional tablets, clinical improvements were maintained over a month study period in patients who continued to receive galantamine therapy. However, as with other anticholinesterase inhibitors e.

   
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